Aromasin ®

Generic Name: Exemestane

Drug Type:

Aromasin is a hormone therapy. Aromasin is classified as an "aromatase inhibitor." (For more detail see "How Aromasin Works" below).

What Aromasin Is Used For:

Aromasin is used to treat advanced breast cancer in post-menopausal women whose disease has progressed following tamoxifen therapy.
Approved for adjuvant treatment of post-menopausal women with estrogen receptor positive early breast cancer who have received 2 to 3 years of tamoxifen therapy and are switched to Aromasin to complete a total of 5 consecutive years of adjuvant hormonal therapy.

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How Aromasin Is Given:

Aromasin is taken by mouth, in tablet form, once a day
Aromasin should be taken after a meal

Side Effects of Aromasin:

Important things to remember about the side effects of Aromasin:

Most people do not experience all of the side effects listed.
Side effects are often predictable in terms of their onset and duration.
Side effects are almost always reversible and will go away after treatment is complete.
There are many options to help minimize or prevent side effects.
There is no relationship between the presence or severity of side effects and the effectiveness of the medication.

The following side effects are common (occurring in greater than 30%) for patients taking Aromasin:

There are no common side effects of Aromasin.

These side effects are less common side effects (occurring in about 10-29%) of patients receiving Aromasin:

Fatigue
Nausea (mild)
Hot flashes
Depression
Bone pain
Insomnia
Anxiety
Shortness of breath

Not all side effects are listed above. Some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms.

When To Contact Your Doctor or Health Care Provider:

Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:

Shortness of breath or difficulty breathing
Having thoughts or feeling like you may want to harm yourself or others

The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:

Nausea (interferes with ability to eat and unrelieved with prescribed medication)
Extreme fatigue (unable to carry on self-care activities)
Depressed (interfering with your ability to carry on your regular activities)

Always inform your health care provider if you experience any unusual symptoms.

Aromasin Precautions:

Before starting Aromasin treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Aromasin may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).
For both men and women: Do not conceive a child (get pregnant) while taking Aromasin. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.
Do not breast feed while taking Aromasin.

Aromasin Self Care Tips:

Take Aromasin after a meal; at about the same time every day.
Aromasin causes little nausea. But if you should experience nausea, take anti-nausea medications as prescribed by your doctor, and eat small frequent meals. Sucking on lozenges and chewing gum may also help.
In general, drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor.
If you are experiencing hot flashes, wearing light clothing, staying in a cool environment, and putting cool cloths on your head may reduce symptoms. Consult you health care provider if these worsen, or become intolerable.
Acetaminophen or ibuprophen may help relieve discomfort from fever, headache and/or generalized aches and pains. However, be sure to talk with your doctor before taking it.
Get plenty of rest.
Maintain good nutrition.
If you experience symptoms or side effects, be sure to discuss them with your health care team. They can prescribe medications and/or offer other suggestions that are effective in managing such problems.

Monitoring and Testing While Taking Aromasin:

You will be monitored regularly by your doctor while you are taking Aromasin, but no special tests are required.

How Aromasin Works:

Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. For example, the hormone testosterone made in the testicles and is responsible for male characteristics such as deepening voice and increased body hair. The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells. Hormone therapies work by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell. The different types of hormone therapies are categorized by their function and/or the type of hormone that is affected.

Aromasin is an aromatase inhibitor. This means it blocks the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink.

Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.